The purpose of hazard identification is to evaluate the weight of evidence for adverse effects in humans based on assessment of all available data on toxicity and mode of action. It is designed to address primarily two questions: (a) whether an agent may pose a health hazard to humans, and (b) under what circumstances an identified hazard may be expressed. Hazard identification is based on analyses of a variety of data that may range from observations in humans to analysis of structure-activity relationships.